常見例句Electron microscopy and flow cytometry were used to demonstrate apoptotic changes in AS ODN treated cells. Results Both AS ODNs inhibited proliferation of BGC 823 cells. 應(yīng)用相差顯微鏡、電子顯微鏡、流式細(xì)胞術(shù)等方法,觀察bcl?2 ASODN 誘導(dǎo)BGC?823 胃癌細(xì)胞凋亡的效果。The inhibitory effect of partial phosphorothioate AS ODN (BCR-ABL AS ODN or C-MYB AS ODN) was as strong as complete phosphorothioat AS ODN with same sequence on CML cell. 部分硫代化的BCR-ABL AS ODN及C-MYB AS ODN對(duì)CML細(xì)胞的抑制作用與完全硫代化的同種AS ODN相當(dāng),而對(duì)正常造血細(xì)胞抑制作用較弱。Objective To investigate the efficacy of autologous bone marrow transplantation(ABMT) for patients with chronic myelogenous leukemia(CML) after in vitro purging of the graft with bcr/abl antisense oligodeoxynucleotides(AS ODN). 目的 觀察bcr/abl反義寡核苷酸 (AS ODN)凈化后自體骨髓移植 (ABMT)治療慢性粒細(xì)胞白血病 (CML)的療效。AS ODN of XIAP+MRP did not enhance the inhibition expression of XIAP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly as compared with AS ODN of XIAP (P 二者聯(lián)合應(yīng)用與XIAP反義寡核苷酸單獨(dú)應(yīng)用比較;并不能增強(qiáng)對(duì)XIAP表達(dá)的抑制作用(P>0.;05);但使HL-60/ADR細(xì)胞對(duì)柔紅霉素的敏感性明顯增加(PAS ODN of XIAP+MRP did not increase the concentration of DNR nor enhanced the inhibition expression of MRP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly (P 二者聯(lián)合應(yīng)用與MRP反義寡核苷酸單獨(dú)應(yīng)用比較;并不能提高HL-60/ADR細(xì)胞內(nèi)DNR濃度及增強(qiáng)對(duì)MRP表達(dá)的抑制作用;卻使HL-60/ADR細(xì)胞對(duì)柔紅霉素的敏感性明顯增加(PThey denounced him to the police as a criminal. 他們向警方告發(fā)他是罪犯。 返回 AS-ODN