Braf

基本解釋

Mutational activation of the BRAF oncogene is the most common genetic alteration in cutaneous melanoma.
BRAF癌基因突變的激活是皮膚黑色素瘤最常見的基因改變。
BRAF related molecules in MAPK signal transduction are potential treatment target of MM.
BRAF突變相關的MAPK信號傳導分子是治療惡性黑素瘤的靶點。
The BRAF mutation found in nevi and melanoma increases the activity of the BRAF protein, prompting cells to multiply abnormally.
BRAF蛋白在調控生長以及分化的信號通路中有重要的作用。而這種突變使得BRAF蛋白的活性增強，進而加速了異常的增殖。
It's still controversial about the relationship of BRAF mutation with heredity, pre-existing pigment nevi, invasion and prognosis of MM.
此突變與遺傳、預先存在的色素痣、腫瘤侵襲性及預后之間的關系還存在爭論。
It is recognized now that RAS, ERK, especially BRAF kinase in the MAPK/ERK pathway probably play important roles in the development of MM.
目前認為,該信號轉導路徑中的RAS、ERK,尤其是BRAF激酶在黑素瘤的發(fā)生發(fā)展中可能有重要作用。