insulin receptor

基本解釋

In order for a cell to respond directly to insulin it must display an insulin receptor on its surface.
為了使一個細胞能夠直接對胰島素做出反應，因此在它表面必須有一個胰島素受體。
To confirm this, the researchers gave the insulin receptor-deficient mice osteocalcin, which improved their metabolic abnormalities.
為了驗證這一說法，研究者們給這些缺少胰島素受體的實驗小鼠們注入了骨鈣蛋白，而這一舉動確實改善了它們的代謝反?，F(xiàn)象。
International Diabetes: Doctor do you think that the modulation of Insulin receptor signaling is the major method to improvement insulin resistance?
國際糖尿病：教授，您認為調(diào)節(jié)胰島素受體信號是改善胰島素抵抗的主要方法嗎？
www.idiabetes.com.cn

It gets enhanced because when insulin binds to the insulin receptor, it activates the receptor.
這種增強效應來自于,胰島素與胰島素受體結合后,就激活了該受體
耶魯公開課 - 生物醫(yī)學工程探索課程節(jié)選
Insulin, the ligand binds to its receptor, creates a change through a kinase activity that's exposed, which leads to other biochemical changes, which leads to a change in cell behavior - in this case the cell behavior is that more glucose transporters are brought to the membrane and more glucose can enter the cell.
胰島素,一種能夠與受體結合的配體,通過其暴露出的激酶活性引起的變化,導致了其它后續(xù)生化變化的發(fā)生,進而使細胞行為發(fā)生改變,這個例子中的細胞行為就是,更多的糖載體被帶到細胞膜表面,這樣更多的糖分子進入到細胞內(nèi)部
耶魯公開課 - 生物醫(yī)學工程探索課程節(jié)選

Sometimes it is a normal gene that directs the production of a hormone, such as insulin, or of the cell machinery which that hormone stimulates, such as the insulin receptor.
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We will routinely turn off genes that promote disease and aging such as the fat insulin receptor gene that tells the fat cells to hold onto excess fat.
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